Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 8/20 | 0.68 |
| ▸ | MAPK10 | P53779 | 8/20 | 0.68 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.52 |
| ▸ | JAK2 | O60674 | 6/20 | 0.49 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.42 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3746004 | 0.92 | MAPK8 (0.81) | MAPK8MAPK10MAPK9JAK2CAMK2D | |
| SCHEMBL3753760 | 0.89 | MAPK10 (0.84) | MAPK8MAPK10MAPK9JAK2CAMK2D | |
| SCHEMBL3748227 | 0.88 | MAPK10 (0.86) | MAPK8MAPK10MAPK9JAK2CAMK2D | |
| SCHEMBL3760571 | 0.85 | MAPK8 (0.65) | MAPK8MAPK10MAPK9JAK2CAMK2D | |
| SCHEMBL3752892 | 0.84 | MAPK8 (0.78) | MAPK8MAPK10MAPK9JAK2JAK3 | |
| SCHEMBL3764962 | 0.81 | MAPK8 (0.61) | MAPK8MAPK10MAPK9JAK2CAMK2D | |
| SCHEMBL3760565 | 0.81 | MAPK10 (1.00) | MAPK8MAPK10MAPK9JAK2CAMK2D | |
| SCHEMBL8051697 | 0.81 | MAPK8 (0.58) | MAPK8MAPK10MAPK9JAK2JAK3 | |
| SCHEMBL3758673 | 0.81 | MAPK10 (0.84) | MAPK8MAPK10MAPK9JAK2JAK3 | |
| SCHEMBL3753577 | 0.80 | MAPK10 (0.79) | MAPK8MAPK10MAPK9JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200436-B1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | SCRIPPS RESEARCH INST (US) | 2015-01-21 | — | — | EP | disclosed |