Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 11/20 | 0.70 |
| ▸ | MAPK8 | P45983 | 8/20 | 0.70 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.54 |
| ▸ | JAK2 | O60674 | 8/20 | 0.52 |
| ▸ | JAK3 | P52333 | 3/20 | 0.51 |
| ▸ | AURKA | O14965 | 2/20 | 0.50 |
| ▸ | CDK4 | P11802 | 2/20 | 0.50 |
| ▸ | CDK2 | P24941 | 2/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.50 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.50 |
| ▸ | JAK1 | P23458 | 2/20 | 0.49 |
| ▸ | CDC7 | O00311 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | CIT | O14578 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | GAK | O14976 | 1/20 | 0.49 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3748934 | 0.87 | MAPK10 (0.69) | MAPK10MAPK8MAPK9JAK2JAK3 | |
| SCHEMBL3761364 | 0.85 | MAPK10 (0.72) | MAPK10MAPK8MAPK9JAK2JAK3 | |
| SCHEMBL3752884 | 0.83 | MAPK10 (0.72) | MAPK10MAPK8MAPK9JAK2JAK3 | |
| SCHEMBL3752672 | 0.82 | MAPK8 (1.00) | MAPK10MAPK8MAPK9JAK2JAK3 | |
| SCHEMBL3750767 | 0.80 | MAPK10 (0.73) | MAPK10MAPK8MAPK9JAK2JAK3 | |
| SCHEMBL3756296 | 0.79 | MAPK10 (0.82) | MAPK10MAPK8MAPK9JAK2JAK3 | |
| SCHEMBL8058492 | 0.78 | MAPK10 (0.70) | MAPK10MAPK8MAPK9JAK2JAK3 | |
| SCHEMBL3760565 | 0.77 | MAPK10 (1.00) | MAPK10MAPK8MAPK9JAK2JAK3 | |
| SCHEMBL3748793 | 0.77 | MAPK10 (0.74) | MAPK10MAPK8MAPK9JAK2JAK3 | |
| SCHEMBL3759032 | 0.77 | MAPK10 (0.67) | MAPK10MAPK8MAPK9JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200436-B1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | SCRIPPS RESEARCH INST (US) | 2015-01-21 | — | — | EP | disclosed |