Sugi Predict

Sugi Predict / Compounds / SCHEMBL1640703

SCHEMBL1640703

SCHEMBL1640703

Fc1ccc(-c2ncn(C3CCN(Cc4ccccn4)C3)c2-c2ccncn2)cc1

nearest known ligand 0.53

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ MAPK14 Q16539 18/20 0.53
▸ EGFR P00533 2/20 0.52
▸ CSNK1D P48730 2/20 0.51
▸ CSNK1E P49674 2/20 0.51
▸ MAPK13 O15264 4/20 0.47
▸ MAPK12 P53778 4/20 0.47
▸ MAPK11 Q15759 4/20 0.47
▸ KCNH2 Q12809 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15203489 0.93 CSNK1D (0.54) MAPK14EGFRCSNK1DCSNK1EMAPK13
SCHEMBL15203507 0.88 EGFR (0.53) MAPK14EGFRCSNK1DCSNK1EMAPK13
SCHEMBL15203548 0.88 MAPK14 (0.50) MAPK14EGFRCSNK1DCSNK1EMAPK13
SCHEMBL15203509 0.87 MAPK14 (0.58) MAPK14EGFRCSNK1DCSNK1EMAPK13
SCHEMBL15203522 0.87 CSNK1D (0.49) MAPK14EGFRCSNK1DCSNK1EMAPK13
SCHEMBL1639785 0.87 CSNK1D (0.60) MAPK14EGFRCSNK1DCSNK1EMAPK13
SCHEMBL1639202 0.86 MAPK14 (0.72) MAPK14EGFRCSNK1DCSNK1EMAPK13
SCHEMBL1640903 0.86 CSNK1D (0.49) MAPK14EGFRCSNK1DCSNK1EMAPK13
SCHEMBL15203534 0.86 CSNK1D (0.49) MAPK14EGFRCSNK1DCSNK1EMAPK13
SCHEMBL1640975 0.86 CSNK1D (0.69) MAPK14EGFRCSNK1DCSNK1EMAPK13

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102686580-B imidazole derivatives as casein kinase inhibitors PFIZER 2014-09-10 — — CN disclosed
EP-2493876-B1 IMIDAZOLE DERIVATIVES AS CASEIN KINASE INHIBITORS PFIZER (US) 2014-02-12 — — EP disclosed
US-8518944-B2 Compounds as casein kinase inhibitors PFIZER INC. (US) 2013-08-27 — — US disclosed
US-20110098272-A1 Novel Compounds As Casein Kinase Inhibitors PFIZER INC 2011-04-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110098272-A1 Novel Compounds As Casein Kinase Inhibitors CSNK1A1, CSNK1A1L, CSNK1G1 MAPK14 169/4885EGFR 771/4885CSNK1D 12/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.