Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.78 |
| ▸ | MTOR | P42345 | 7/20 | 0.78 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.56 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.56 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.52 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16411763 | 0.88 | PIK3CA (0.84) | PIK3CAMTORPIK3CDHDAC1PIK3CG | |
| SCHEMBL1113976 | 0.80 | PIK3CA (0.67) | PIK3CAMTORPIK3CDHDAC1PIK3CG | |
| SCHEMBL1114139 | 0.80 | PIK3CA (1.00) | PIK3CAMTORPIK3CDHDAC1PIK3CG | |
| SCHEMBL2865554 | 0.80 | PIK3CA (0.62) | PIK3CAMTORPIK3CDHDAC1PIK3CG | |
| SCHEMBL1114205 | 0.78 | PIK3CA (0.73) | PIK3CAMTORPIK3CDHDAC1PIK3CG | |
| SCHEMBL1114313 | 0.77 | PIK3CA (0.66) | PIK3CAMTORPIK3CDHDAC1PIK3CG | |
| SCHEMBL16411842 | 0.77 | PIK3CA (0.63) | PIK3CAMTORPIK3CDHDAC1PIK3CG | |
| SCHEMBL1114197 | 0.77 | PIK3CA (0.65) | PIK3CAMTORPIK3CDHDAC1PIK3CG | |
| SCHEMBL1113410 | 0.76 | PIK3CA (0.64) | PIK3CAMTORPIK3CDHDAC1PIK3CG | |
| SCHEMBL16412048 | 0.76 | PIK3CA (0.64) | PIK3CAMTORPIK3CDHDAC1PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2279188-B1 | PURINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH INC (US) | 2015-01-28 | — | — | EP | claimed |