Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 10/20 | 0.42 |
| ▸ | LPAR3 | Q9UBY5 | 6/20 | 0.42 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.41 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.41 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.41 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.41 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 5/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | AKT2 | P31751 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | FABP1 | P07148 | 1/20 | 0.31 |
| ▸ | FABP4 | P15090 | 1/20 | 0.31 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4349 | 0.90 | LPAR1 (0.51) | LPAR1LPAR3ABCC3ABCC4ABCB11 | |
| SCHEMBL4144 | 0.88 | LPAR1 (0.52) | LPAR1LPAR3ABCC3ABCC4ABCB11 | |
| SCHEMBL5093 | 0.84 | LPAR1 (0.41) | LPAR1LPAR3ABCC3ABCC4ABCB11 | |
| SCHEMBL10390 | 0.82 | LPAR1 (0.45) | LPAR1LPAR3ABCC3ABCC4ABCB11 | |
| SCHEMBL4818 | 0.82 | LPAR1 (0.42) | LPAR1LPAR3ABCC3ABCC4ABCB11 | |
| SCHEMBL3474 | 0.81 | LPAR1 (0.46) | LPAR1LPAR3ABCC3ABCC4ABCB11 | |
| SCHEMBL10250 | 0.80 | LPAR1 (0.46) | LPAR1LPAR3ABCC3ABCC4ABCB11 | |
| SCHEMBL3696 | 0.79 | LPAR1 (0.49) | LPAR1LPAR3ABCC3ABCC4ABCB11 | |
| SCHEMBL3695 | 0.79 | LPAR1 (0.54) | LPAR1LPAR3ABCC3ABCC4ABCB11 | |
| SCHEMBL6945 | 0.78 | LPAR1 (0.54) | LPAR1LPAR3ABCC3ABCC4ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3024456-A1 | COMBINATORIAL METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF BISANTRENE | Update Pharma Inc. (US) | 2016-06-01 | — | — | EP | disclosed |
| WO-2015013581-A1 | COMBINATORIAL METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF BISANTRENE | UPDATE PHARMA INC. (US) | 2015-01-29 | — | — | WO | disclosed |