Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARK3 | P27448 | 15/20 | 0.65 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.65 |
| ▸ | SGK1 | O00141 | 4/20 | 0.65 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.65 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.65 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.65 |
| ▸ | NUAK1 | O60285 | 4/20 | 0.65 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.65 |
| ▸ | JAK2 | O60674 | 4/20 | 0.65 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.65 |
| ▸ | RAF1 | P04049 | 4/20 | 0.65 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.65 |
| ▸ | LCK | P06239 | 4/20 | 0.65 |
| ▸ | CSF1R | P07333 | 4/20 | 0.65 |
| ▸ | MET | P08581 | 4/20 | 0.65 |
| ▸ | HCK | P08631 | 4/20 | 0.65 |
| ▸ | PIM1 | P11309 | 4/20 | 0.65 |
| ▸ | SRC | P12931 | 4/20 | 0.65 |
| ▸ | BRAF | P15056 | 4/20 | 0.65 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15168715 | 1.00 | MARK3 (0.65) | MARK3ROCK2SGK1CHEK1MAPK13 | |
| SCHEMBL15169038 | 0.94 | MARK3 (0.67) | MARK3ROCK2SGK1CHEK1MAPK13 | |
| SCHEMBL15168999 | 0.94 | MARK3 (0.67) | MARK3ROCK2SGK1CHEK1MAPK13 | |
| SCHEMBL16418181 | 0.92 | MARK3 (0.65) | MARK3ROCK2SGK1CHEK1MAPK13 | |
| SCHEMBL15169218 | 0.92 | MARK3 (0.65) | MARK3ROCK2SGK1CHEK1MAPK13 | |
| SCHEMBL15187436 | 0.92 | MARK3 (0.65) | MARK3ROCK2SGK1CHEK1MAPK13 | |
| SCHEMBL15187450 | 0.92 | MARK3 (0.67) | MARK3ROCK2SGK1CHEK1MAPK13 | |
| SCHEMBL2225886 | 0.92 | MARK3 (0.67) | MARK3ROCK2SGK1CHEK1MAPK13 | |
| SCHEMBL15168633 | 0.91 | MARK3 (0.68) | MARK3ROCK2SGK1CHEK1MAPK13 | |
| SCHEMBL15169017 | 0.91 | MARK3 (0.68) | MARK3ROCK2SGK1CHEK1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523552-B1 | PYRAZOLO[1,5-A]PYRIMIDINES AS MARK INHIBITORS | MERCK SHARP & DOHME (US) | 2015-05-13 | — | — | EP | claimed |
| US-8946237-B2 | Pyrazolo[1,5-A]pyrimidines as mark inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-02-03 | — | — | US | claimed |