Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN3 | Q9H6Z9 | 4/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1640587 | 0.90 | EGLN3 (0.73) | EGLN3KDM4ELMNAALDH1A1ALOX12 | |
| SCHEMBL12727318 | 0.88 | EGLN3 (0.74) | EGLN3MEN1KMT2AEGLN1NPC1 | |
| SCHEMBL1641768 | 0.88 | EGLN3 (0.74) | EGLN3MEN1KMT2AEGLN1NPC1 | |
| SCHEMBL1642196 | 0.88 | EGLN3 (0.56) | EGLN3KDM4ELMNAALDH1A1ALOX12 | |
| SCHEMBL12727430 | 0.86 | EGLN3 (0.76) | EGLN3MEN1KMT2AEGLN1NPC1 | |
| SCHEMBL12727427 | 0.85 | EGLN3 (0.71) | EGLN3MEN1KMT2AEGLN1NPC1 | |
| SCHEMBL1641912 | 0.85 | EGLN3 (0.71) | EGLN3MEN1KMT2AEGLN1NPC1 | |
| SCHEMBL1642088 | 0.85 | EGLN3 (0.70) | EGLN3MEN1KMT2AEGLN1NPC1 | |
| SCHEMBL1642025 | 0.84 | EGLN3 (0.70) | EGLN3LMNAMEN1KMT2AEGLN1 | |
| SCHEMBL12727420 | 0.84 | EGLN3 (0.73) | EGLN3MEN1KMT2AEGLN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110098324-A1 | PROLYL HYDROXYLASE INHIBITORS | GLAXOSMITHKLINE LLC | 2011-04-28 | — | — | US | disclosed |
| US-20110098324-A1 | PROLYL HYDROXYLASE INHIBITORS | GLAXOSMITHKLINE LLC | 2011-04-28 | — | — | US | disclosed |
| US-20110098324-A1 | PROLYL HYDROXYLASE INHIBITORS | GLAXOSMITHKLINE LLC | 2011-04-28 | — | — | US | disclosed |
| WO-2009158315-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098324-A1 | PROLYL HYDROXYLASE INHIBITORS | HIF1AN, EGLN2, EGLN3 | EGLN3 3/4885KDM4E 521/4885LMNA 3462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.