Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 19/20 | 1.00 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.67 |
| ▸ | PRKDC | P78527 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2482627 | 1.00 | ATR (1.00) | ATRTYRO3PRKDC | |
| SCHEMBL13138647 | 1.00 | ATR (1.00) | ATRTYRO3PRKDC | |
| SCHEMBL17826560 | 0.91 | ATR (0.92) | ATRPRKDC | |
| SCHEMBL2486742 | 0.91 | ATR (1.00) | ATRPRKDC | |
| SCHEMBL3054929 | 0.89 | ATR (1.00) | ATR | |
| SCHEMBL2510765 | 0.87 | ATR (1.00) | ATRPRKDC | |
| SCHEMBL3461011 | 0.86 | ATR (0.74) | ATRTYRO3 | |
| SCHEMBL2484673 | 0.86 | ATR (1.00) | ATRPRKDC | |
| SCHEMBL3460413 | 0.84 | ATR (0.72) | ATRTYRO3 | |
| SCHEMBL20283909 | 0.83 | ATR (0.71) | ATRPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4059932-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | Vertex Pharmaceuticals Incorporated (US) | 2022-09-21 | — | — | EP | disclosed |
| US-20150031661-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150031661-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | ATR, CHEK1, MAP3K5 | ATR 1/4885TYRO3 946/4885PRKDC 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.