Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 10/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.43 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.43 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.43 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16430048 | 1.00 | KCNA5 (0.46) | KCNA5KCNH2CYP3A4CYP2C9KCNA3 | |
| SCHEMBL14662358 | 0.82 | KMT2A (0.48) | KMT2AMEN1GSK3AGSK3BPOLB | |
| SCHEMBL16875993 | 0.78 | TACR1 (0.42) | KMT2APOLB | |
| SCHEMBL16430114 | 0.77 | KMT2A (0.47) | CYP3A4KMT2AMEN1GSK3AGSK3B | |
| SCHEMBL16429897 | 0.77 | KMT2A (0.48) | KMT2AMEN1GSK3AGSK3BPOLB | |
| SCHEMBL16430127 | 0.77 | KMT2A (0.48) | KMT2AMEN1GSK3AGSK3BPOLB | |
| SCHEMBL16430468 | 0.77 | KMT2A (0.47) | CYP3A4KMT2AMEN1GSK3AGSK3B | |
| SCHEMBL16429891 | 0.76 | KMT2A (0.47) | KMT2AMEN1GSK3AGSK3BSIGMAR1 | |
| SCHEMBL16430124 | 0.76 | KMT2A (0.48) | CYP3A4KMT2AMEN1GSK3AGSK3B | |
| SCHEMBL16426901 | 0.76 | SMN1; SMN2 (0.40) | KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3027601-A1 | SYK INHIBITORS | Gilead Sciences, Inc. (US) | 2016-06-08 | — | — | EP | disclosed |
| WO-2015017610-A1 | SYK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2015-02-05 | — | — | WO | disclosed |