Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16440384 | 0.92 | MAPT (0.73) | MAPTSMN1; SMN2LMNARXFP1GAA | |
| SCHEMBL16434502 | 0.83 | MAPT (0.55) | MAPTSMN1; SMN2LMNARXFP1GAA | |
| SCHEMBL10114670 | 0.79 | MAPT (0.82) | MAPTSMN1; SMN2LMNARXFP1CYP1A2 | |
| SCHEMBL18166618 | 0.79 | MAPT (0.79) | MAPTSMN1; SMN2LMNARXFP1CYP1A2 | |
| SCHEMBL9972920 | 0.78 | MAPT (0.77) | MAPTSMN1; SMN2LMNARXFP1CYP1A2 | |
| SCHEMBL3265924 | 0.78 | MAPT (0.71) | MAPTSMN1; SMN2LMNARXFP1CYP1A2 | |
| SCHEMBL18166649 | 0.78 | SMN1; SMN2 (0.82) | MAPTSMN1; SMN2LMNARXFP1CYP1A2 | |
| SCHEMBL27793543 | 0.78 | MAPT (0.79) | MAPTSMN1; SMN2LMNARXFP1CYP1A2 | |
| SCHEMBL18166643 | 0.77 | RXFP1 (0.72) | MAPTSMN1; SMN2LMNARXFP1CYP1A2 | |
| SCHEMBL10114087 | 0.77 | MAPT (1.00) | MAPTSMN1; SMN2LMNARXFP1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2832731-A1 | AROMATIC HETEROCYCLIC FIVE-MEMBERED RING DERIVATIVE HAVING TRPV4 INHIBITORY ACTIVITY | Shionogi & Co., Ltd. (JP) | 2015-02-04 | — | — | EP | disclosed |