⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1401001 | 0.85 | — | — | |
| SCHEMBL6364044 | 0.83 | — | — | |
| SCHEMBL385626 | 0.72 | — | — | |
| SCHEMBL823130 | 0.69 | — | — | |
| SCHEMBL6629206 | 0.68 | — | — | |
| SCHEMBL18499412 | 0.67 | — | — | |
| SCHEMBL261785 | 0.67 | — | — | |
| SCHEMBL12087107 | 0.64 | — | — | |
| SCHEMBL261789 | 0.64 | — | — | |
| SCHEMBL9244981 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101258152-A | Pyridopyrimidine derivatives as PDE4 inhibitors for the treatment of inflammatory and immune diseases | ASTRAZENECA AB (SE) | 2008-09-03 | — | — | CN | claimed |
| CN-1290165-A | Benzothiazole Protein tyrosine kinase inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2001-04-04 | — | — | CN | claimed |
| US-20230158017-A1 | METHODS FOR TREATING DEPRESSIVE SYMPTOMS | JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT | 2023-05-25 | — | — | US | disclosed |
| US-11534436-B2 | Methods for treating depressive symptoms | ALKERMES PHARMA IRELAND LIMITED (IE) | 2022-12-27 | — | — | US | disclosed |
| EP-3781574-A1 | MACROCYCLIC SPIROETHERS AS MCL-1 INHIBITORS | Ascentage Pharma (Suzhou) Co., Ltd. (CN) | 2021-02-24 | — | — | EP | disclosed |
| US-20210000818-A1 | METHODS FOR TREATING DEPRESSIVE SYMPTOMS | JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT | 2021-01-07 | — | — | US | disclosed |
| US-10752592-B2 | Morphan and morphinan analogues, and methods of use | ALKERMES PHARMA IRELAND LIMITED (IE) | 2020-08-25 | — | — | US | disclosed |
| US-10736890-B2 | Methods for treating depressive symptoms | ALKERMES PHARMA IRELAND LIMITED (IE) | 2020-08-11 | — | — | US | disclosed |
| WO-2020147802-A1 | MACROCYCLIC SPIROETHERS AS MCL-1 INHIBITORS | ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) | 2020-07-23 | — | — | WO | disclosed |
| EP-3004114-B1 | MORPHAN AND MORPHINAN ANALOGUES, AND METHODS OF USE | ALKERMES PHARMA IRELAND LTD (IE) | 2019-12-25 | — | — | EP | disclosed |
| US-20190218185-A1 | Morphan And Morphinan Analogues, And Methods Of Use | JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT | 2019-07-18 | — | — | US | disclosed |
| CN-101495152-A | Preparation of polymer conjugates of vla-4 antagonists via a mitsunobu' s reaction | ELAN PHARM INC (US) | 2009-07-29 | — | — | CN | disclosed |
| CN-101432129-A | Novel compounds that are useful for improving pharmacokinetics | ABBOTT LAB (US) | 2009-05-13 | — | — | CN | disclosed |
| CN-101405265-A | Amido compounds and their use as pharmaceuticals | INCYTE CORP (US) | 2009-04-08 | — | — | CN | disclosed |
| CN-101309922-A | Amino-aza-adamantane derivatives and methods of use | ABBOTT LAB (US) | 2008-11-19 | — | — | CN | disclosed |
| CN-101258152-A | Pyridopyrimidine derivatives as PDE4 inhibitors for the treatment of inflammatory and immune diseases | ASTRAZENECA AB (SE) | 2008-09-03 | — | — | CN | disclosed |
| CN-101142172-A | Inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1 enzyme | ABBOTT LAB (US) | 2008-03-12 | — | — | CN | disclosed |
| CN-101137616-A | Inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1 enzyme | ABBOTT LAB (US) | 2008-03-05 | — | — | CN | disclosed |
| CN-1279026-C | Prostaglandin endoperoxide H synthase biosynthesis inhibitors | ABBOTT LAB (US) | 2006-10-11 | — | — | CN | disclosed |
| CN-1342149-A | Prostaglandin endoperoxide H synthase biosynthesis inhibitors | ABBOTT LAB (US) | 2002-03-27 | — | — | CN | disclosed |