Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 12/20 | 0.68 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.61 |
| ▸ | SRC | P12931 | 2/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.61 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.61 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | CSF1R | P07333 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.55 |
| ▸ | CDK4 | P11802 | 1/20 | 0.54 |
| ▸ | CCND1 | P24385 | 1/20 | 0.54 |
| ▸ | CCND2 | P30279 | 1/20 | 0.54 |
| ▸ | CCND3 | P30281 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16454985 | 0.90 | WEE1 (0.69) | WEE1FGFR4SRCFGFR1FGFR2 | |
| SCHEMBL31557302 | 0.84 | WEE1 (0.83) | WEE1FGFR4SRCFGFR1FGFR2 | |
| SCHEMBL14875643 | 0.84 | WEE1 (0.83) | WEE1FGFR4SRCFGFR1FGFR2 | |
| SCHEMBL14875699 | 0.83 | WEE1 (0.86) | WEE1FGFR4SRCFGFR1FGFR2 | |
| SCHEMBL31557074 | 0.83 | WEE1 (0.86) | WEE1FGFR4SRCFGFR1FGFR2 | |
| SCHEMBL30878430 | 0.83 | SRC (0.65) | WEE1FGFR4SRCFGFR1FGFR2 | |
| SCHEMBL30878475 | 0.82 | SRC (0.63) | WEE1FGFR4SRCFGFR1FGFR2 | |
| SCHEMBL31557079 | 0.81 | WEE1 (1.00) | WEE1FGFR4SRCFGFR1FGFR2 | |
| SCHEMBL14875677 | 0.81 | WEE1 (1.00) | WEE1FGFR4SRCFGFR1FGFR2 | |
| SCHEMBL31557251 | 0.80 | WEE1 (1.00) | WEE1FGFR4SRCFGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015019037-A1 | PHARMACEUTICAL COMPOUNDS | ALMAC DISCOVERY LIMITED (GB) | 2015-02-12 | — | — | WO | disclosed |
| WO-2015019037-A1 | PHARMACEUTICAL COMPOUNDS | ALMAC DISCOVERY LIMITED (GB) | 2015-02-12 | — | — | WO | disclosed |