Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 7/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.39 |
| ▸ | SOAT1 | P35610 | 3/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | PIP4K2A | P48426 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16446508 | 0.90 | PDE4B (0.60) | PDE4BPDE4DPTGS2PIP4K2APTGS1 | |
| SCHEMBL16446938 | 0.89 | PDE4B (0.82) | PDE4BPTGS2PIP4K2APTGS1KMO | |
| SCHEMBL16445876 | 0.86 | PDE4B (0.68) | PDE4BPDE4DPTGS2PIP4K2APTGS1 | |
| SCHEMBL16446337 | 0.79 | PDE4B (1.00) | PDE4BPTGS2PIP4K2AKMO | |
| SCHEMBL16446831 | 0.78 | PDE4B (0.53) | PDE4BPDE4DDGAT1SOAT1PTGS2 | |
| SCHEMBL16446524 | 0.78 | PDE4B (0.79) | PDE4BPDE4DPTGS2PTGS1 | |
| SCHEMBL17784216 | 0.78 | PDE4B (1.00) | PDE4BPDE4DPTGS2PTGS1 | |
| SCHEMBL16447006 | 0.77 | PDE4B (0.64) | PDE4BPTGS2PTGS1LMNA | |
| SCHEMBL16447005 | 0.77 | PDE4B (0.64) | PDE4BPTGS2PTGS1LMNA | |
| SCHEMBL16447024 | 0.77 | PDE4B (0.74) | PDE4BPDE4DPTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3030565-B1 | NOVEL SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2017-07-19 | — | — | EP | disclosed |
| US-9688683-B2 | Substituted condensed pyrimidine compounds | Grünenthal GmbH (DE) | 2017-06-27 | — | — | US | disclosed |
| EP-3030565-A1 | NOVEL SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS | Grünenthal GmbH (DE) | 2016-06-15 | — | — | EP | disclosed |
| US-20160152624-A1 | NOVEL SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS | Grünenthal GmbH (DE) | 2016-06-02 | — | — | US | disclosed |
| WO-2015018534-A1 | NOVEL SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS | Grünenthal GmbH (DE) | 2015-02-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160152624-A1 | NOVEL SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS | PDE4A, PDE4B, TYMP | PDE4B 2/4885PDE4D 8/4885DGAT1 3391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.