Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | GUCY1B2 | O75343 | 14/20 | 0.44 |
| ▸ | GUCY1A2 | P33402 | 14/20 | 0.44 |
| ▸ | GUCY1A1 | Q02108 | 14/20 | 0.44 |
| ▸ | GUCY1B1 | Q02153 | 14/20 | 0.44 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16447935 | 0.88 | GUCY1B2 (0.46) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL15686189 | 0.82 | GUCY1B2 (0.64) | SMN1; SMN2GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL16447936 | 0.79 | GUCY1B2 (0.39) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL10644161 | 0.79 | GUCY1B2 (0.68) | SMN1; SMN2GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL16447922 | 0.78 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPK1HCRTR1TP53MAPT | |
| SCHEMBL16447820 | 0.75 | GUCY1B2 (0.44) | MAPTKDM4EALDH1A1GUCY1B2GUCY1A2 | |
| SCHEMBL14232517 | 0.74 | GUCY1B2 (0.48) | SMN1; SMN2GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL15630704 | 0.73 | GUCY1B2 (0.47) | SMN1; SMN2GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL16447761 | 0.72 | GUCY1B2 (0.47) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL6937081 | 0.70 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPK1HCRTR1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160176880-A1 | SUBSTITUTED IMIDAZO[1,2-A]PYRAZINECARBOXAMIDES AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-06-23 | — | — | US | disclosed |
| US-20160176880-A1 | SUBSTITUTED IMIDAZO[1,2-A]PYRAZINECARBOXAMIDES AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-06-23 | — | — | US | disclosed |
| US-20160176880-A1 | SUBSTITUTED IMIDAZO[1,2-A]PYRAZINECARBOXAMIDES AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-06-23 | — | — | US | disclosed |
| EP-3030564-A1 | SUBSTITUTED IMIDAZO[1,2-A]PYRAZINECARBOXAMIDES AND USE THEREOF | Bayer Pharma Aktiengesellschaft (DE) | 2016-06-15 | — | — | EP | disclosed |
| WO-2015018808-A1 | SUBSTITUTED IMIDAZO[1,2-A]PYRAZINECARBOXAMIDES AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-02-12 | — | — | WO | disclosed |
| WO-2015018808-A1 | SUBSTITUTED IMIDAZO[1,2-A]PYRAZINECARBOXAMIDES AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-02-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160176880-A1 | SUBSTITUTED IMIDAZO[1,2-A]PYRAZINECARBOXAMIDES AND USE THEREOF | AADAC, PAICS, TPMT | SMN1; SMN2 1890/4885MAPK1 2961/4885HCRTR1 1855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.