Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 20/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16446517 | 0.87 | CFTR (0.53) | CFTR | |
| SCHEMBL16446418 | 0.83 | CFTR (0.51) | CFTR | |
| SCHEMBL16450537 | 0.80 | CFTR (0.71) | CFTR | |
| SCHEMBL16446773 | 0.79 | CFTR (0.53) | CFTR | |
| SCHEMBL21248056 | 0.73 | CFTR (0.59) | CFTR | |
| SCHEMBL25798608 | 0.71 | CFTR (0.58) | CFTR | |
| SCHEMBL16450584 | 0.67 | CFTR (0.75) | CFTR | |
| SCHEMBL16445644 | 0.67 | CFTR (1.00) | CFTR | |
| SCHEMBL16445829 | 0.66 | CFTR (0.70) | CFTR | |
| SCHEMBL16445884 | 0.66 | CFTR (0.65) | CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3030568-A1 | THIENO[2,3-C]PYRANS AS CFTR MODULATORS | Galapagos NV (BE) | 2016-06-15 | — | — | EP | claimed |
| WO-2015018823-A1 | THIENO[2,3-C]PYRANS AS CFTR MODULATORS | GALAPAGOS NV (BE) | 2015-02-12 | — | — | WO | claimed |