Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 18/20 | 0.70 |
| ▸ | PDE4A | P27815 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16448675 | 1.00 | SCN9A (0.70) | SCN9APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16448674 | 0.84 | SCN9A (0.66) | SCN9ASCN5A | |
| SCHEMBL16448671 | 0.84 | SCN9A (0.66) | SCN9ASCN5A | |
| SCHEMBL16448542 | 0.82 | SCN9A (1.00) | SCN9ASCN5A | |
| SCHEMBL16448537 | 0.82 | SCN9A (1.00) | SCN9ASCN5A | |
| SCHEMBL16448539 | 0.82 | SCN9A (1.00) | SCN9ASCN5A | |
| SCHEMBL17423075 | 0.82 | SCN9A (0.69) | SCN9ASCN5A | |
| SCHEMBL16448538 | 0.79 | SCN9A (1.00) | SCN9ASCN5A | |
| SCHEMBL16448541 | 0.79 | SCN9A (1.00) | SCN9ASCN5A | |
| SCHEMBL16448656 | 0.77 | SCN9A (0.72) | SCN9ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8952169-B2 | N-substituted benzamides and methods of use thereof | XENON PHARMACEUTICALS INC. (CA) | 2015-02-10 | — | — | US | disclosed |
| US-8952169-B2 | N-substituted benzamides and methods of use thereof | XENON PHARMACEUTICALS INC. (CA) | 2015-02-10 | — | — | US | disclosed |