Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fasiglifam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 known ✓ | O14842 | 20/20 | 1.00 |
| ▸ | GNA15 | P30679 | 1/20 | 1.00 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 1.00 |
| ▸ | ABCC2 | Q92887 | 1/20 | 1.00 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 1.00 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fasiglifam SCHEMBL16448782 | 1.00 | FFAR1 (1.00) | FFAR1GNA15SLC10A1ABCC2SLCO1B3 | |
| Fasiglifam SCHEMBL31192643 | 1.00 | FFAR1 (1.00) | FFAR1GNA15SLC10A1ABCC2SLCO1B3 | |
| Fasiglifam SCHEMBL29360096 | 1.00 | FFAR1 (1.00) | FFAR1GNA15SLC10A1ABCC2SLCO1B3 | |
| Fasiglifam SCHEMBL204652 | 1.00 | FFAR1 (1.00) | FFAR1GNA15SLC10A1ABCC2SLCO1B3 | |
| SCHEMBL17471350 | 0.95 | FFAR1 (1.00) | FFAR1GNA15SLC10A1ABCC2SLCO1B3 | |
| SCHEMBL207981 | 0.95 | FFAR1 (0.90) | FFAR1GNA15SLC10A1ABCC2SLCO1B3 | |
| SCHEMBL18058590 | 0.94 | FFAR1 (0.88) | FFAR1GNA15SLC10A1ABCC2SLCO1B3 | |
| SCHEMBL14309260 | 0.92 | FFAR1 (0.85) | FFAR1GNA15SLC10A1ABCC2SLCO1B3 | |
| SCHEMBL22215870 | 0.92 | FFAR1 (0.85) | FFAR1GNA15SLC10A1ABCC2SLCO1B3 | |
| SCHEMBL2690226 | 0.92 | FFAR1 (0.85) | FFAR1GNA15SLC10A1ABCC2SLCO1B3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8952185-B2 | Production method of optically active dihydrobenzofuran derivative | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-02-10 | — | — | US | disclosed |
| US-8952185-B2 | Production method of optically active dihydrobenzofuran derivative | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-02-10 | — | — | US | disclosed |