Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.60 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.59 |
| ▸ | CTSG | P08311 | 1/20 | 0.59 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.59 |
| ▸ | CMA1 | P23946 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | ESRRG | P62508 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | NAAA | Q02083 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25752880 | 0.89 | PRSS1 (0.67) | POLBPRSS1CTSGCTRB1CMA1 | |
| SCHEMBL10224288 | 0.85 | PRSS1 (0.67) | POLBPRSS1CTSGCTRB1CMA1 | |
| SCHEMBL5020903 | 0.84 | PRSS1 (0.61) | POLBPRSS1CTSGCTRB1CMA1 | |
| SCHEMBL28788762 | 0.83 | PRSS1 (0.59) | POLBPRSS1CTSGCTRB1CMA1 | |
| SCHEMBL21590340 | 0.80 | PRSS1 (0.65) | POLBPRSS1CTSGCTRB1CMA1 | |
| SCHEMBL30914530 | 0.79 | PRSS1 (0.63) | POLBPRSS1CTSGCTRB1CMA1 | |
| SCHEMBL5676158 | 0.79 | PRSS1 (0.63) | POLBPRSS1CTSGCTRB1CMA1 | |
| SCHEMBL7676183 | 0.79 | PRSS1 (0.63) | POLBPRSS1CTSGCTRB1CMA1 | |
| SCHEMBL28440839 | 0.79 | PRSS1 (0.73) | POLBPRSS1CTSGCTRB1CMA1 | |
| SCHEMBL16156086 | 0.79 | PRSS1 (0.63) | POLBPRSS1CTSGCTRB1CMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8952150-B2 | Prostaglandin transporter inhibitors and uses thereof | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2015-02-10 | — | — | US | disclosed |