Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3322776 | 0.81 | PDE10A (0.45) | PDE10AP2RX7HSD17B10NPC1RAB9A | |
| SCHEMBL8244075 | 0.75 | PDE10A (0.59) | PDE10AHSD17B10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31487019 | 0.75 | PDE10A (0.59) | PDE10AHSD17B10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL95592 | 0.74 | PDE10A (0.58) | PDE10AHSD17B10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5901373 | 0.73 | PDE10A (0.51) | PDE10AHSD17B10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3960135 | 0.73 | PDE10A (0.51) | PDE10AHSD17B10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3960133 | 0.73 | PDE10A (0.51) | PDE10AHSD17B10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12111148 | 0.73 | PDE10A (0.56) | PDE10AHSD17B10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10158220 | 0.73 | PDE10A (0.56) | PDE10AHSD17B10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31486540 | 0.73 | PDE10A (0.56) | PDE10AHSD17B10NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8981086-B2 | Phosphine-ligated palladium sulfonate palladacycles | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2015-03-17 | — | — | US | disclosed |
| US-20150045570-A1 | PHOSPHINE-LIGATED PALLADIUM SULFONATE PALLADACYCLES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150045570-A1 | PHOSPHINE-LIGATED PALLADIUM SULFONATE PALLADACYCLES | PHOSPHO1, PDCD1, PDCD1LG2 | PDE10A 1064/4885P2RX7 2626/4885HSD17B10 4381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.