Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 15/20 | 0.58 |
| ▸ | CTSL | P07711 | 2/20 | 0.53 |
| ▸ | CTSB | P07858 | 2/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.50 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.50 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1645644 | 1.00 | BACE1 (0.58) | BACE1CTSLCTSBPTGS2AKR1B10 | |
| Hydrochloric Acid SCHEMBL1645748 | 0.89 | BACE1 (0.56) | BACE1PTGS2AKR1B10AKR1B1MAOB | |
| SCHEMBL1646637 | 0.89 | BACE1 (0.56) | BACE1CTSLCTSBPTGS2AKR1B10 | |
| SCHEMBL1646634 | 0.89 | BACE1 (0.56) | BACE1CTSLCTSBPTGS2AKR1B10 | |
| Hydrochloric Acid SCHEMBL1645745 | 0.89 | BACE1 (0.56) | BACE1PTGS2AKR1B10AKR1B1MAOB | |
| SCHEMBL1647088 | 0.85 | DRD4 (0.49) | BACE1 | |
| SCHEMBL1647085 | 0.85 | DRD4 (0.49) | BACE1 | |
| SCHEMBL1646680 | 0.83 | ABCB1 (0.49) | BACE1CTSLCTSBMAOB | |
| SCHEMBL15295429 | 0.83 | ABCB1 (0.49) | BACE1CTSLCTSBMAOB | |
| SCHEMBL1647378 | 0.82 | GRIN2D (0.57) | BACE1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8552220-B2 | Therapeutic agent for Alzheimer's disease | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2013-10-08 | — | — | US | disclosed |
| EP-2305629-A1 | THERAPEUTIC AGENT FOR ALZHEIMER'S DISEASE | Tokyo Institute of Technology (JP) | 2011-04-06 | — | — | EP | disclosed |