SCHEMBL16456763

SCHEMBL16456763

Cc1cc(OCc2c(-c3c(Cl)cccc3Cl)noc2C(C)C)ccc1-c1ccc2cc(C(=O)O)sc2c1

nearest known ligand 0.73

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NR1H4 Q96RI1 20/20 0.73
LIFR P42702 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16456698 0.90 NR1H4 (0.69) NR1H4
SCHEMBL16456751 0.88 NR1H4 (0.71) NR1H4
SCHEMBL2084127 0.86 NR1H4 (0.65) NR1H4LIFR
SCHEMBL2083938 0.85 NR1H4 (0.80) NR1H4LIFR
SCHEMBL2084624 0.85 NR1H4 (0.65) NR1H4LIFR
SCHEMBL2813400 0.84 NR1H4 (1.00) NR1H4LIFR
SCHEMBL2082700 0.84 NR1H4 (0.83) NR1H4LIFR
SCHEMBL2001397 0.84 NR1H4 (1.00) NR1H4
SCHEMBL2083720 0.84 NR1H4 (0.73) NR1H4LIFR
SCHEMBL16456784 0.83 NR1H4 (0.64) NR1H4LIFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1984360-B1 Compounds and methods for modulating FX-receptors LILLY CO ELI (US) 2014-01-15 EP disclosed