Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 18/20 | 0.66 |
| ▸ | RPS6KB1 | P23443 | 7/20 | 0.66 |
| ▸ | PRKCB | P05771 | 4/20 | 0.66 |
| ▸ | RPS6KA1 | Q15418 | 4/20 | 0.66 |
| ▸ | AKT3 | Q9Y243 | 13/20 | 0.40 |
| ▸ | AKT2 | P31751 | 10/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16457366 | 1.00 | AKT1 (0.66) | AKT1RPS6KB1PRKCBRPS6KA1AKT3 | |
| SCHEMBL16457490 | 0.95 | AKT1 (0.68) | AKT1RPS6KB1PRKCBRPS6KA1AKT3 | |
| SCHEMBL16457491 | 0.95 | AKT1 (0.68) | AKT1RPS6KB1PRKCBRPS6KA1AKT3 | |
| SCHEMBL16457141 | 0.92 | AKT1 (0.65) | AKT1RPS6KB1PRKCBRPS6KA1AKT3 | |
| SCHEMBL16457139 | 0.92 | AKT1 (0.65) | AKT1RPS6KB1PRKCBRPS6KA1AKT3 | |
| SCHEMBL9894241 | 0.90 | AKT1 (0.80) | AKT1RPS6KB1PRKCBRPS6KA1 | |
| SCHEMBL9894563 | 0.90 | RPS6KB1 (0.78) | AKT1RPS6KB1PRKCBRPS6KA1 | |
| SCHEMBL9894561 | 0.90 | RPS6KB1 (0.78) | AKT1RPS6KB1PRKCBRPS6KA1 | |
| SCHEMBL16457804 | 0.90 | AKT1 (0.59) | AKT1RPS6KB1PRKCBRPS6KA1AKT3 | |
| SCHEMBL16457805 | 0.90 | AKT1 (0.59) | AKT1RPS6KB1PRKCBRPS6KA1AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491032-B1 | AKT INHIBITORS | LILLY CO ELI (US) | 2014-04-16 | — | — | EP | disclosed |