Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1662370 | 0.88 | TP53 (0.43) | TP53LMNATHRBMAPTKDM4E | |
| SCHEMBL16457484 | 0.88 | TP53 (0.45) | TP53LMNATHRBMAPTKDM4E | |
| SCHEMBL16457464 | 0.88 | NSD2 (0.47) | TP53LMNATHRBMAPTKDM4E | |
| SCHEMBL9894068 | 0.88 | TP53 (0.44) | TP53LMNATHRBMAPTKDM4E | |
| SCHEMBL16457354 | 0.88 | TP53 (0.43) | TP53LMNATHRBMAPTKDM4E | |
| SCHEMBL1662356 | 0.88 | TP53 (0.43) | TP53LMNATHRBMAPTKDM4E | |
| SCHEMBL16457314 | 0.88 | RPS6KB1 (0.47) | TP53LMNATHRBMAPTKDM4E | |
| SCHEMBL16457382 | 0.87 | RPS6KB1 (0.48) | TP53LMNATHRBMAPTKDM4E | |
| SCHEMBL16457520 | 0.87 | TP53 (0.42) | TP53LMNATHRBMAPTKDM4E | |
| SCHEMBL16457394 | 0.87 | RPS6KB1 (0.50) | TP53LMNATHRBMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491032-B1 | AKT INHIBITORS | LILLY CO ELI (US) | 2014-04-16 | — | — | EP | disclosed |