Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.56 |
| ▸ | PARP1 | P09874 | 5/20 | 0.45 |
| ▸ | CDC7 | O00311 | 6/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.39 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.39 |
| ▸ | PIM1 | P11309 | 3/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | CIT | O14578 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.38 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9605019 | 1.00 | SCN10A (0.56) | SCN10APARP1CDC7CCNE1CDK2 | |
| Hydrochloric Acid SCHEMBL1646698 | 0.99 | SCN10A (0.55) | SCN10APARP1CDC7CCNE1CDK2 | |
| SCHEMBL12509313 | 0.98 | SCN10A (0.58) | SCN10APARP1CDC7CCNE1CDK2 | |
| SCHEMBL1293660 | 0.94 | SCN10A (0.54) | SCN10APARP1CDC7CCNE1CDK2 | |
| SCHEMBL12798837 | 0.93 | SCN10A (0.63) | SCN10APARP1CDC7CCNE1CDK2 | |
| SCHEMBL11939401 | 0.89 | SCN10A (0.52) | SCN10APARP1CDC7CCNE1CDK2 | |
| SCHEMBL1293911 | 0.88 | SCN10A (0.58) | SCN10APARP1NR1H4AAK1USP30 | |
| SCHEMBL1293913 | 0.88 | SCN10A (0.58) | SCN10APARP1NR1H4AAK1USP30 | |
| SCHEMBL19700991 | 0.88 | SCN10A (0.58) | SCN10APARP1NR1H4AAK1USP30 | |
| SCHEMBL12053448 | 0.88 | SCN10A (0.67) | SCN10APARP1AAK1USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8623899-B2 | Bis-benzimidazole derivatives as hepatitis C virus inhibitors | Janssen Research & Development Ireland (IE) | 2014-01-07 | — | — | US | disclosed |
| US-8623899-B2 | Bis-benzimidazole derivatives as hepatitis C virus inhibitors | Janssen Research & Development Ireland (IE) | 2014-01-07 | — | — | US | disclosed |
| US-20120135953-A1 | Bis-Benzimidazole Derivatives As Hepatitis C Virus Inhibitors | TIBOTEC PHARMACEUTICALS (IE) | 2012-05-31 | — | — | US | disclosed |
| WO-2011050146-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-04-28 | — | — | WO | disclosed |
| WO-2011050146-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-04-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120135953-A1 | Bis-Benzimidazole Derivatives As Hepatitis C Virus Inhibitors | HAVCR2, ZC3HAV1, CCNI | SCN10A 4559/4885PARP1 1074/4885CDC7 2262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.