Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.46 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.46 |
| ▸ | RPS6KA1 | Q15418 | 2/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | PKM | P14618 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.34 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.34 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL691627 | 0.76 | PTK2 (0.45) | MAPK1MAPK3RPS6KA1PTK2NPC1 | |
| SCHEMBL1293067 | 0.73 | MAPK1 (0.77) | MAPK1MAPK3RPS6KA1PTK2KDM4E | |
| SCHEMBL690192 | 0.73 | MAPK1 (0.66) | MAPK1MAPK3RPS6KA1PTK2KDM4E | |
| SCHEMBL690133 | 0.72 | MAPK1 (0.55) | MAPK1MAPK3RPS6KA1PTK2 | |
| SCHEMBL1293012 | 0.72 | PTK2 (0.59) | MAPK1MAPK3RPS6KA1PTK2ALDH1A1 | |
| SCHEMBL691964 | 0.71 | MAPK1 (0.63) | MAPK1MAPK3RPS6KA1PTK2KDM4E | |
| SCHEMBL22174998 | 0.71 | PTK2 (0.62) | MAPK1MAPK3RPS6KA1PTK2KDM4E | |
| SCHEMBL12102982 | 0.71 | PTK2 (0.60) | MAPK1MAPK3RPS6KA1PTK2MEN1 | |
| SCHEMBL697233 | 0.71 | PTK2 (0.60) | MAPK1MAPK3PTK2MAPTMEN1 | |
| SCHEMBL690564 | 0.70 | PTK2 (0.61) | MAPK1MAPK3RPS6KA1PTK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140107131-A1 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2014-04-17 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140107131-A1 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK | PTK2, PAK1, CTTN | MAPK1 221/4885MAPK3 64/4885RPS6KA1 136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.