Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 17/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 14/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16460058 | 0.88 | RPS6KB1 (0.59) | AURKAAURKBRPS6KB1 | |
| SCHEMBL16460449 | 0.88 | AURKA (0.56) | AURKAAURKBRPS6KB1 | |
| SCHEMBL16460395 | 0.85 | AURKA (0.59) | AURKAAURKBRPS6KB1 | |
| SCHEMBL16459771 | 0.85 | AURKA (0.68) | AURKAAURKBRPS6KB1 | |
| SCHEMBL16460035 | 0.83 | AURKA (0.59) | AURKAAURKBRPS6KB1 | |
| SCHEMBL16459940 | 0.83 | RPS6KB1 (0.56) | AURKAAURKBRPS6KB1 | |
| SCHEMBL665161 | 0.81 | AURKA (0.59) | AURKAAURKBRPS6KB1 | |
| SCHEMBL664474 | 0.80 | AURKA (0.69) | AURKAAURKBRPS6KB1 | |
| SCHEMBL665573 | 0.80 | AURKA (0.48) | AURKAAURKBRPS6KB1 | |
| SCHEMBL16459802 | 0.78 | AURKA (0.59) | AURKAAURKBRPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9040560-B2 | Amino azaheterocyclic carboxamides | MERCK PATENT GMBH (DE) | 2015-05-26 | — | — | US | disclosed |
| US-20140107156-A1 | Novel Amino Azaheterocyclic Carboxamides | MERCK PATENT GMBH (DE) | 2014-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140107156-A1 | Novel Amino Azaheterocyclic Carboxamides | AZI2, MKI67, MYC | AURKA 600/4885AURKB 550/4885RPS6KB1 500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.