SCHEMBL16467494

SCHEMBL16467494

O=CCN1CCC(c2nsc(Nc3ncc(Sc4ccnc5ccsc45)cc3Oc3ccccc3C(F)(F)F)n2)CC1

nearest known ligand 0.47

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GCK P35557 16/20 0.47
KDR P35968 4/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16467501 0.90 GCK (0.55) GCK
SCHEMBL16467519 0.90 GCK (0.44) GCKKDR
SCHEMBL16467449 0.89 GCK (0.48) GCKKDR
SCHEMBL1330244 0.89 GCK (0.61) GCKKDR
SCHEMBL16467230 0.87 GCK (0.54) GCK
Hydrochloric Acid SCHEMBL3600566 0.87 GCK (0.44) GCKKDR
SCHEMBL16467545 0.85 GCK (0.42) GCKKDR
SCHEMBL16467279 0.80 GCK (0.56) GCK
SCHEMBL16467506 0.80 GCK (0.48) GCKKDR
Hydrochloric Acid SCHEMBL2657431 0.79 GCK (0.56) GCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2013204-B1 2-AMINOPYRIDINE ANALOGS AS GLUCOKINASE ACTIVATORS ARRAY BIOPHARMA INC (US) 2015-02-18 EP claimed