Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | HTT | P42858 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 3/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1645272 | 0.85 | SMN1; SMN2 (0.60) | SMN1; SMN2THRBL3MBTL1MAPTHTT | |
| SCHEMBL1646096 | 0.85 | SMN1; SMN2 (0.60) | SMN1; SMN2THRBL3MBTL1MAPTHTT | |
| SCHEMBL1646824 | 0.80 | SMN1; SMN2 (0.55) | SMN1; SMN2THRBL3MBTL1MAPTHTT | |
| SCHEMBL20847069 | 0.79 | SMN1; SMN2 (0.53) | SMN1; SMN2THRBL3MBTL1MAPTHTT | |
| SCHEMBL1646027 | 0.78 | SMN1; SMN2 (0.57) | SMN1; SMN2THRBL3MBTL1MAPTHTT | |
| SCHEMBL1646486 | 0.77 | SMN1; SMN2 (0.56) | SMN1; SMN2THRBL3MBTL1MAPTHTT | |
| SCHEMBL1644537 | 0.77 | SMN1; SMN2 (0.59) | SMN1; SMN2THRBL3MBTL1MAPTHTT | |
| SCHEMBL1646339 | 0.76 | SMN1; SMN2 (0.49) | SMN1; SMN2THRBL3MBTL1MAPTHTT | |
| SCHEMBL1645698 | 0.76 | SMN1; SMN2 (0.58) | SMN1; SMN2THRBL3MBTL1MAPTHTT | |
| SCHEMBL3890455 | 0.75 | SMN1; SMN2 (0.50) | SMN1; SMN2THRBL3MBTL1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2303329-A1 | ANTIFUNGAL COMBINATION THERAPY | F2G Limited (GB) | 2011-04-06 | — | — | EP | claimed |
| WO-2009144473-A1 | ANTIFUNGAL COMBINATION THERAPY | F2G LIMITED (GB) | 2009-12-03 | — | — | WO | claimed |