Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.97 |
| ▸ | LMNA | P02545 | 2/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.97 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.97 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.97 |
| ▸ | RAB9A | P51151 | 1/20 | 0.97 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.97 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | CTSK | P43235 | 3/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carisoprodol SCHEMBL158375 | 0.98 | TSHR (1.00) | TSHRLMNACYP3A4NFKB1ADRA1A | |
| Carisoprodol SCHEMBL2232476 | 0.98 | TSHR (1.00) | TSHRLMNACYP3A4NFKB1ADRA1A | |
| Carisoprodol SCHEMBL8379174 | 0.98 | TSHR (1.00) | TSHRLMNACYP3A4NFKB1ADRA1A | |
| Carisoprodol SCHEMBL33286 | 0.98 | TSHR (1.00) | TSHRLMNACYP3A4NFKB1ADRA1A | |
| Carisoprodol SCHEMBL23856096 | 0.97 | TSHR (0.97) | TSHRLMNACYP3A4NFKB1ADRA1A | |
| Carisoprodol SCHEMBL10448685 | 0.97 | TSHR (0.97) | TSHRLMNACYP3A4NFKB1ADRA1A | |
| Carisoprodol SCHEMBL10713646 | 0.97 | TSHR (0.97) | TSHRLMNACYP3A4NFKB1ADRA1A | |
| Carisoprodol SCHEMBL21633327 | 0.97 | TSHR (0.97) | TSHRLMNACYP3A4NFKB1ADRA1A | |
| Carisoprodol SCHEMBL9498806 | 0.96 | TSHR (0.94) | TSHRLMNACYP3A4NFKB1ADRA1A | |
| Carisoprodol SCHEMBL7565198 | 0.96 | TSHR (0.94) | TSHRLMNACYP3A4NFKB1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160194631-A1 | Methods for Modulation of Autophagy Through the Modulation of Autophagy-Inhibiting Gene Products | HARVARD MEDICAL SCHOOL (US) | 2016-07-07 | — | — | US | disclosed |
| US-20140004108-A1 | Methods for Modulation of Autophagy Through the Modulation of Autophagy-Enhancing Gene Products | HARVARD MEDICAL SCHOOL (US) | 2014-01-02 | — | — | US | disclosed |
| US-20120315244-A1 | Methods for Modulation of Autophagy Through the Modulation of Autophagy-Inhibiting Gene Products | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2012-12-13 | — | — | US | disclosed |
| US-20120301463-A1 | Methods for Modulation of Autophagy Through the Modulation of Autophagy-Enhancing Gene Products | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-11-29 | — | — | US | disclosed |
| EP-2483406-A2 | METHODS FOR MODULATION OF AUTOPHAGY THROUGH THE MODULATION OF AUTOPHAGY-INHIBITING GENE PRODUCTS | President and Fellows of Harvard College (US) | 2012-08-08 | — | — | EP | disclosed |
| EP-2483407-A2 | METHODS FOR MODULATION OF AUTOPHAGY THROUGH THE MODULATION OF AUTOPHAGY-ENHANCING GENE PRODUCTS | President and Fellows of Harvard College (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041582-A2 | METHODS FOR MODULATION OF AUTOPHAGY THROUGH THE MODULATION OF AUTOPHAGY-INHIBITING GENE PRODUCTS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-04-07 | — | — | WO | disclosed |
| WO-2011041584-A2 | METHODS FOR MODULATION OF AUTOPHAGY THROUGH THE MODULATION OF AUTOPHAGY-ENHANCING GENE PRODUCTS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-04-07 | — | — | WO | disclosed |