Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 15/20 | 0.67 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.54 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.47 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1647116 | 1.00 | BACE1 (0.67) | BACE1HDAC3HDAC6NCOR2AKR1B10 | |
| SCHEMBL1648279 | 0.85 | BACE1 (0.64) | BACE1HDAC3HDAC6NCOR2 | |
| SCHEMBL1648276 | 0.85 | BACE1 (0.64) | BACE1HDAC3HDAC6NCOR2 | |
| SCHEMBL1647362 | 0.84 | BACE1 (0.71) | BACE1AKR1B10AKR1B1MAOBPTGS2 | |
| SCHEMBL1647359 | 0.84 | BACE1 (0.71) | BACE1AKR1B10AKR1B1MAOBPTGS2 | |
| SCHEMBL1646957 | 0.81 | BACE1 (1.00) | BACE1 | |
| SCHEMBL1646956 | 0.81 | BACE1 (1.00) | BACE1 | |
| SCHEMBL3220854 | 0.81 | BCHE (0.60) | BACE1HDAC3HDAC6NCOR2AKR1B10 | |
| SCHEMBL3220867 | 0.81 | BCHE (0.60) | BACE1HDAC3HDAC6NCOR2AKR1B10 | |
| SCHEMBL1648589 | 0.79 | BACE1 (1.00) | BACE1AKR1B10AKR1B1MAOBPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8552220-B2 | Therapeutic agent for Alzheimer's disease | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2013-10-08 | — | — | US | disclosed |
| EP-2305629-A1 | THERAPEUTIC AGENT FOR ALZHEIMER'S DISEASE | Tokyo Institute of Technology (JP) | 2011-04-06 | — | — | EP | disclosed |