Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADM2 | Q7Z4H4 | 9/20 | 0.52 |
| ▸ | CALCRL | Q16602 | 11/20 | 0.51 |
| ▸ | CALCB | P10092 | 8/20 | 0.51 |
| ▸ | RAMP1 | O60894 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1815456 | 0.89 | CALCRL (0.51) | ADM2CALCRLCALCBRAMP1 | |
| SCHEMBL29996226 | 0.89 | CALCRL (0.51) | ADM2CALCRLCALCBRAMP1 | |
| SCHEMBL7030609 | 0.89 | CALCRL (0.51) | ADM2CALCRLCALCBRAMP1 | |
| SCHEMBL13376816 | 0.88 | CALCRL (0.49) | ADM2CALCRLCALCBRAMP1 | |
| SCHEMBL31084970 | 0.87 | CALCRL (0.51) | ADM2CALCRLCALCBRAMP1 | |
| SCHEMBL15236128 | 0.87 | CALCRL (0.51) | ADM2CALCRLCALCBRAMP1 | |
| SCHEMBL12655038 | 0.87 | CALCRL (0.51) | ADM2CALCRLCALCBRAMP1 | |
| SCHEMBL22796626 | 0.87 | CALCRL (0.51) | ADM2CALCRLCALCBRAMP1 | |
| SCHEMBL29416274 | 0.87 | CALCRL (0.51) | ADM2CALCRLCALCBRAMP1 | |
| SCHEMBL29517886 | 0.87 | CALCRL (0.51) | ADM2CALCRLCALCBRAMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912653-B1 | HETEROCYCLIC BENZODIAZEPINE CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2014-01-01 | — | — | EP | disclosed |