Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 18/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1647250 | 1.00 | BACE1 (0.60) | BACE1NFKB1NFKB2RELAAPP | |
| SCHEMBL1645385 | 0.88 | BACE1 (0.64) | BACE1APPMAPT | |
| SCHEMBL1645383 | 0.88 | BACE1 (0.64) | BACE1APPMAPT | |
| SCHEMBL1648153 | 0.80 | BACE1 (0.71) | BACE1 | |
| SCHEMBL1648151 | 0.80 | BACE1 (0.71) | BACE1 | |
| SCHEMBL1645574 | 0.80 | ERN1 (0.43) | NFKB1NFKB2RELA | |
| SCHEMBL1648281 | 0.76 | BACE1 (1.00) | BACE1 | |
| SCHEMBL1648285 | 0.76 | BACE1 (1.00) | BACE1 | |
| SCHEMBL1646430 | 0.76 | BACE1 (0.84) | BACE1 | |
| SCHEMBL1646431 | 0.76 | BACE1 (0.84) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8552220-B2 | Therapeutic agent for Alzheimer's disease | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2013-10-08 | — | — | US | disclosed |
| EP-2305629-A1 | THERAPEUTIC AGENT FOR ALZHEIMER'S DISEASE | Tokyo Institute of Technology (JP) | 2011-04-06 | — | — | EP | disclosed |