Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 20/20 | 0.82 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1131955 | 0.97 | GCK (0.84) | GCKKCNH2 | |
| SCHEMBL2668968 | 0.92 | GCK (0.94) | GCKKCNH2 | |
| SCHEMBL1107433 | 0.90 | GCK (1.00) | GCKKCNH2 | |
| SCHEMBL16473167 | 0.89 | GCK (0.66) | GCKKCNH2 | |
| SCHEMBL9892947 | 0.89 | GCK (0.72) | GCKKCNH2 | |
| SCHEMBL12742067 | 0.88 | GCK (0.90) | GCKKCNH2 | |
| SCHEMBL1132358 | 0.86 | GCK (0.73) | GCKKCNH2 | |
| SCHEMBL9891661 | 0.85 | GCK (0.68) | GCKKCNH2 | |
| SCHEMBL1107343 | 0.83 | GCK (0.66) | GCKKCNH2 | |
| SCHEMBL1107463 | 0.83 | GCK (0.87) | GCKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2059522-B1 | PHOSPHONATE AND PHOSPHINATE COMPOUNDS AS GLUCOKINASE ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2014-01-08 | — | — | EP | disclosed |