Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 13/20 | 0.43 |
| ▸ | JAK2 | O60674 | 11/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17772161 | 0.90 | KDM1A (0.42) | NTRK1JAK2RIPK1 | |
| SCHEMBL16474299 | 0.85 | OPRL1 (0.42) | NTRK1RIPK1OPRM1 | |
| SCHEMBL28796117 | 0.84 | NTRK1 (0.45) | NTRK1JAK2OPRM1 | |
| SCHEMBL28950329 | 0.84 | NTRK1 (0.42) | NTRK1JAK2OPRM1 | |
| SCHEMBL24200617 | 0.84 | NTRK1 (0.43) | NTRK1JAK2OPRM1 | |
| SCHEMBL16474297 | 0.82 | SLC6A2 (0.46) | — | |
| SCHEMBL16474301 | 0.82 | NTRK1 (0.46) | NTRK1JAK2RIPK1OPRM1 | |
| SCHEMBL28682432 | 0.82 | NTRK1 (0.44) | NTRK1JAK2 | |
| SCHEMBL19547163 | 0.82 | NTRK1 (0.43) | NTRK1JAK2RIPK1 | |
| SCHEMBL19547185 | 0.81 | NTRK1 (0.46) | NTRK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109890820-B | Aminopyrazolopyrimidine compounds as neurotrophin tyrosine kinase receptor inhibitors | 正大天晴药业集团股份有限公司 | 2020-11-03 | — | — | CN | disclosed |
| CN-108003161-B | Neurotrophic factor tyrosine kinase receptor inhibitors | 正大天晴药业集团股份有限公司 | 2020-10-09 | — | — | CN | disclosed |
| US-10758542-B2 | Substituted pyrazolo[l,5-a]pyrimidine compounds as Trk kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2020-09-01 | — | — | US | disclosed |
| US-10251889-B2 | Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors | Array BioPharm Inc. (US) | 2019-04-09 | — | — | US | disclosed |
| EP-2451812-B1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2017-11-08 | — | — | EP | disclosed |
| EP-2350071-B1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2014-01-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10251889-B2 | Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors | TXK, FRK, LTK | NTRK1 7/4885JAK2 124/4885RIPK1 319/4885 |
| US-10758542-B2 | Substituted pyrazolo[l,5-a]pyrimidine compounds as Trk kinase inhibitors | LTK, TXK, FRK | NTRK1 7/4885JAK2 133/4885RIPK1 304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.