SCHEMBL1647698

SCHEMBL1647698

NC(=O)CC(c1ccccc1)c1c(O)c2ccccc2oc1=O

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 8/20 0.76
VKORC1 Q9BQB6 3/20 0.76
ALDH1A1 P00352 3/20 0.76
HSD17B10 Q99714 2/20 0.76
ALB P02768 2/20 0.76
KDM4E B2RXH2 2/20 0.76
PCSK7 Q16549 1/20 0.76
MEN1 O00255 1/20 0.76
KMT2A Q03164 1/20 0.76
CYP3A4 P08684 1/20 0.74
NQO1 P15559 1/20 0.66
LMNA P02545 1/20 0.64
GAA P10253 1/20 0.64
HPGD P15428 1/20 0.64
HTT P42858 1/20 0.64
POLB P06746 1/20 0.61
NR1I2 O75469 1/20 0.60
NR3C1 P04150 1/20 0.60
ADRA1A P35348 1/20 0.60
KCNH2 Q12809 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1649909 0.89 CYP2C9 (0.80) CYP2C9VKORC1ALDH1A1HSD17B10ALB
Warfarin SCHEMBL3689 0.86 CYP2C9 (1.00) CYP2C9VKORC1ALDH1A1HSD17B10ALB
Warfarin SCHEMBL3792087 0.86 CYP2C9 (1.00) CYP2C9VKORC1ALDH1A1HSD17B10ALB
Warfarin SCHEMBL29400364 0.86 CYP2C9 (1.00) CYP2C9VKORC1ALDH1A1HSD17B10ALB
Warfarin SCHEMBL2139452 0.86 CYP2C9 (1.00) CYP2C9VKORC1ALDH1A1HSD17B10ALB
Warfarin SCHEMBL662875 0.86 CYP2C9 (1.00) CYP2C9VKORC1ALDH1A1HSD17B10ALB
Warfarin SCHEMBL4439794 0.86 CYP2C9 (1.00) CYP2C9VKORC1ALDH1A1HSD17B10ALB
Warfarin SCHEMBL4757598 0.85 CYP2C9 (0.97) CYP2C9VKORC1ALDH1A1HSD17B10ALB
Warfarin SCHEMBL2597774 0.85 CYP2C9 (0.97) CYP2C9VKORC1ALDH1A1HSD17B10ALB
Warfarin SCHEMBL13278154 0.85 CYP2C9 (0.97) CYP2C9VKORC1ALDH1A1HSD17B10ALB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2161261-B1 Materials and methods for treating coagulation disorders ARMETHEON INC (US) 2013-08-28 EP disclosed
CN-1950353-B Materials and methods for treating coagulation disorders ARYX THERAPEUTICS 2011-06-01 CN disclosed
US-7932405-B2 Halogenated ester derivatives of coumarins for the treatment of coagulation disorders ARYX THERAPEUTICS, INC. (US) 2011-04-26 US disclosed
EP-2161261-A1 Materials and methods for treating coagulation disorders Aryx Therapeutics (US) 2010-03-10 EP disclosed
EP-1735296-B1 MATERIALS AND METHODS FOR TREATING COAGULATION DISORDERS ARYX THERAPEUTICS (US) 2009-12-09 EP disclosed
CN-1950353-A Materials and methods for treating coagulation disorders ARYX THERAPEUTICS (US) 2007-04-18 CN disclosed