Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.88 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1546612 | 0.87 | POLB (0.76) | POLBHSD17B10HPGDMAPTKMT2A | |
| SCHEMBL396705 | 0.86 | KMT2A (0.77) | POLBHSD17B10HPGDGAAMAPT | |
| SCHEMBL1000486 | 0.85 | POLB (0.74) | POLBHSD17B10HPGDMAPTKMT2A | |
| SCHEMBL1649376 | 0.85 | POLB (0.66) | POLBHSD17B10HPGDKMT2AKDM4E | |
| SCHEMBL6207027 | 0.84 | CYP3A4 (0.75) | POLBHSD17B10HPGDGAAMAPT | |
| SCHEMBL28653785 | 0.84 | HSD17B10 (0.77) | POLBHSD17B10HPGDGAAMAPT | |
| SCHEMBL395198 | 0.84 | KMT2A (0.75) | POLBHSD17B10HPGDGAAMAPT | |
| SCHEMBL28655730 | 0.84 | POLB (0.65) | POLBHSD17B10HPGDGAAMAPT | |
| SCHEMBL1645604 | 0.82 | APEX1 (0.72) | POLBHSD17B10HPGDGAAMAPT | |
| Sulfosalicylic SCHEMBL26603634 | 0.81 | KDM4E (0.66) | POLBHSD17B10HPGDGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483254-A1 | NOVEL COMPOUNDS | Glaxo Group Limited (GB) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011038572-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-04-07 | — | — | WO | disclosed |
| EP-2024369-A2 | NOVEL PROCESS FOR THE PREPARATION OF SILDENAFIL CITRATE | Matrix Laboratories Ltd (IN) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007141805-A2 | NOVEL PROCESS FOR THE PREPARATION OF SILDENAFIL CITRATE | MATRIX LABORATORIES LIMITED (IN) | 2007-12-13 | — | — | WO | disclosed |
| WO-2007141805-A2 | NOVEL PROCESS FOR THE PREPARATION OF SILDENAFIL CITRATE | MATRIX LABORATORIES LIMITED (IN) | 2007-12-13 | — | — | WO | disclosed |