Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 9/20 | 0.39 |
| ▸ | CTSC | P53634 | 3/20 | 0.37 |
| ▸ | CTSK | P43235 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.33 |
| ▸ | PRF1 | P14222 | 2/20 | 0.31 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2885215 | 0.82 | CTSC (0.54) | RETCTSCCTSK | |
| SCHEMBL2885213 | 0.82 | CTSC (0.54) | RETCTSCCTSK | |
| SCHEMBL16478185 | 0.81 | RET (0.40) | RETCTSCCTSKMAPK1BDKRB1 | |
| SCHEMBL290037 | 0.79 | RET (0.36) | RETCTSCCTSK | |
| SCHEMBL9886055 | 0.79 | CTSC (0.41) | RETCTSCCTSKMAPK1PRF1 | |
| SCHEMBL290711 | 0.78 | RET (0.37) | RETCTSCCTSK | |
| SCHEMBL300351 | 0.76 | RET (0.35) | RETCTSCCTSK | |
| SCHEMBL16485782 | 0.75 | CTSC (0.48) | RETCTSCCTSK | |
| SCHEMBL2893129 | 0.71 | ECE1 (0.38) | RETCTSCCTSK | |
| SCHEMBL2893127 | 0.71 | ECE1 (0.38) | RETCTSCCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011154677-A1 | SUBSTITUTED N-[1-CYANO-2-(PHENYL)ETHYL] 1-AMINOCYCLOALK-1-YLCARBOXAMIDE COMPOUNDS - 760 | ASTRAZENECA AB (SE) | 2011-12-15 | — | — | WO | disclosed |