Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.31 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16480374 | 1.00 | MAPT (0.49) | MAPTGAATSHRPIK3CDHSD11B1 | |
| SCHEMBL9892998 | 0.81 | PIK3CD (0.42) | MAPTGAATSHRPIK3CDHSD11B1 | |
| SCHEMBL9893119 | 0.81 | PIK3CD (0.42) | MAPTGAATSHRPIK3CDHSD11B1 | |
| SCHEMBL9891885 | 0.81 | PIK3CD (0.42) | MAPTGAATSHRPIK3CDHSD11B1 | |
| SCHEMBL9891830 | 0.81 | PIK3CD (0.42) | MAPTGAATSHRPIK3CDHSD11B1 | |
| SCHEMBL9110238 | 0.80 | ATM (0.50) | MAPTGAAPIK3CDHSD11B1NR1H2 | |
| SCHEMBL9103248 | 0.80 | ATM (0.50) | MAPTGAAPIK3CDHSD11B1NR1H2 | |
| SCHEMBL26926002 | 0.79 | MAPT (0.59) | MAPTGAATSHRPIK3CDHSD11B1 | |
| SCHEMBL19711137 | 0.78 | PIK3CD (0.66) | MAPTGAATSHRPIK3CDATM | |
| SCHEMBL19710877 | 0.76 | PIK3CD (0.65) | MAPTGAATSHRPIK3CDATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8629157-B2 | Pyrrolidine compounds which modulate the CB2 receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-01-14 | — | — | US | disclosed |