Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | PKM | P14618 | 3/20 | 0.36 |
| ▸ | TDO2 | P48775 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL994700 | 0.92 | TDP1 (0.36) | KDM4EMEN1MAPTKMT2ATDP1 | |
| SCHEMBL16470135 | 0.92 | MAPT (0.41) | KDM4EMEN1MAPTKMT2ATDP1 | |
| SCHEMBL27650679 | 0.92 | TDP1 (0.36) | KDM4EMEN1MAPTKMT2ATDP1 | |
| SCHEMBL21099305 | 0.79 | MAPT (0.41) | KDM4EMEN1MAPTKMT2ATDP1 | |
| SCHEMBL4712057 | 0.79 | EGFR (0.39) | KDM4EMEN1MAPTKMT2ATDP1 | |
| SCHEMBL29970861 | 0.77 | CYP1A2 (0.41) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL26131871 | 0.77 | CYP1A2 (0.37) | MEN1MAPTKMT2ATDP1ALDH1A1 | |
| SCHEMBL26131807 | 0.77 | CYP1A2 (0.41) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL29969235 | 0.77 | CYP1A2 (0.37) | MEN1MAPTKMT2ATDP1ALDH1A1 | |
| SCHEMBL21050767 | 0.76 | MAPT (0.37) | KDM4EMEN1MAPTKMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3033343-A1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF MEK | Novartis AG (CH) | 2016-06-22 | — | — | EP | disclosed |
| WO-2015022662-A1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF MEK | NOVARTIS AG (CH) | 2015-02-19 | — | — | WO | disclosed |
| WO-2015022664-A1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF MEK | NOVARTIS AG (CH) | 2015-02-19 | — | — | WO | disclosed |