Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 2/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.62 |
| ▸ | ABL1 | P00519 | 1/20 | 0.62 |
| ▸ | RET | P07949 | 1/20 | 0.62 |
| ▸ | FLT3 | P36888 | 1/20 | 0.62 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.62 |
| ▸ | GRK5 | P34947 | 16/20 | 0.57 |
| ▸ | PAK4 | O96013 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16568627 | 1.00 | PDGFRB (0.62) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL16490721 | 1.00 | PDGFRB (0.62) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL16490724 | 1.00 | PDGFRB (0.62) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL16486408 | 1.00 | PDGFRB (0.62) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL16486440 | 0.95 | PDGFRB (0.62) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL16490719 | 0.95 | PDGFRB (0.62) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL16568041 | 0.95 | PDGFRB (0.62) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL16490700 | 0.94 | GRK5 (0.61) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL16486943 | 0.94 | GRK5 (0.61) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL16486361 | 0.94 | GRK5 (0.61) | PDGFRBFGFR1ABL1RETFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015022437-A1 | INDOLINONE DERIVATIVES AS GRK5 MODULATORS | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2015-02-19 | — | — | WO | claimed |
| WO-2015022437-A1 | INDOLINONE DERIVATIVES AS GRK5 MODULATORS | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2015-02-19 | — | — | WO | disclosed |