Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 16/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.41 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1648695 | 1.00 | BACE1 (0.52) | BACE1CA12CA1CA2CA7 | |
| SCHEMBL15295473 | 0.84 | BACE1 (0.53) | BACE1CA12CA1CA2CA7 | |
| SCHEMBL15295472 | 0.84 | BACE1 (0.53) | BACE1CA12CA1CA2CA7 | |
| SCHEMBL1648691 | 0.82 | BACE1 (0.58) | BACE1PTGS2AKR1B10AKR1B1MAOB | |
| SCHEMBL1648694 | 0.82 | BACE1 (0.58) | BACE1PTGS2AKR1B10AKR1B1MAOB | |
| SCHEMBL1645563 | 0.79 | BACE1 (0.52) | BACE1CA12CA1CA2CA7 | |
| SCHEMBL1645571 | 0.79 | BACE1 (0.52) | BACE1CA12CA1CA2CA7 | |
| SCHEMBL1646033 | 0.74 | BACE1 (0.51) | BACE1CA12CA1CA2CA7 | |
| SCHEMBL1646029 | 0.74 | BACE1 (0.51) | BACE1CA12CA1CA2CA7 | |
| SCHEMBL8467685 | 0.74 | AKR1B1 (0.71) | BACE1CA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8552220-B2 | Therapeutic agent for Alzheimer's disease | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2013-10-08 | — | — | US | disclosed |
| EP-2305629-A1 | THERAPEUTIC AGENT FOR ALZHEIMER'S DISEASE | Tokyo Institute of Technology (JP) | 2011-04-06 | — | — | EP | disclosed |