Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.76 |
| ▸ | TSHR | P16473 | 1/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.74 |
| ▸ | TP53 | P04637 | 1/20 | 0.74 |
| ▸ | OGT | O15294 | 9/20 | 0.74 |
| ▸ | POLB | P06746 | 2/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 1/20 | 0.70 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16487941 | 0.88 | MAPT (0.84) | ALDH1A1TSHRHSD17B10SMN1; SMN2TP53 | |
| SCHEMBL16487644 | 0.87 | SMN1; SMN2 (0.80) | ALDH1A1TSHRHSD17B10SMN1; SMN2TP53 | |
| SCHEMBL16487942 | 0.85 | SMN1; SMN2 (1.00) | ALDH1A1TSHRHSD17B10SMN1; SMN2TP53 | |
| SCHEMBL16488006 | 0.85 | OGT (0.79) | ALDH1A1TSHRHSD17B10SMN1; SMN2TP53 | |
| SCHEMBL10132041 | 0.85 | OGT (1.00) | ALDH1A1TSHRHSD17B10SMN1; SMN2TP53 | |
| SCHEMBL16487947 | 0.84 | TP53 (0.85) | ALDH1A1TSHRHSD17B10SMN1; SMN2TP53 | |
| SCHEMBL10131852 | 0.84 | OGT (1.00) | ALDH1A1TSHRHSD17B10SMN1; SMN2TP53 | |
| SCHEMBL4547301 | 0.84 | OGT (1.00) | ALDH1A1TSHRHSD17B10SMN1; SMN2TP53 | |
| SCHEMBL16487943 | 0.84 | OGT (0.77) | ALDH1A1TSHRHSD17B10SMN1; SMN2TP53 | |
| SCHEMBL16487971 | 0.83 | OGT (0.79) | ALDH1A1TSHRHSD17B10SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8957075-B2 | O-GlcNAc transferase inhibitors and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-02-17 | — | — | US | disclosed |
| US-8957075-B2 | O-GlcNAc transferase inhibitors and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-02-17 | — | — | US | disclosed |