Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Benzydamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.95 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.95 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.95 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.95 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.95 |
| ▸ | HTR1A | P08908 | 1/20 | 0.95 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.95 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.95 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.95 |
| ▸ | DRD1 | P21728 | 1/20 | 0.95 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.95 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.95 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.95 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.95 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.95 |
| ▸ | DRD3 | P35462 | 1/20 | 0.95 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.95 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.95 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.95 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.95 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzydamine SCHEMBL29376229 | 0.97 | HRH3 (1.00) | HRH3KDM4EGUCY1B2CYP1A2CHRM2 | |
| Benzydamine SCHEMBL26172 | 0.97 | HRH3 (1.00) | HRH3KDM4EGUCY1B2CYP1A2CHRM2 | |
| Benzydamine SCHEMBL8078518 | 0.96 | HRH3 (0.97) | HRH3KDM4EGUCY1B2CYP1A2CHRM2 | |
| Benzydamine SCHEMBL42644 | 0.96 | POLB (1.00) | HRH3KDM4EGUCY1B2CYP1A2CHRM2 | |
| Benzydamine SCHEMBL42645 | 0.96 | POLB (1.00) | HRH3KDM4EGUCY1B2CYP1A2CHRM2 | |
| SCHEMBL8018576 | 0.94 | KDM4E (0.93) | HRH3KDM4EGUCY1B2CYP1A2CHRM2 | |
| SCHEMBL9917397 | 0.91 | DRD1 (0.88) | HRH3KDM4EGUCY1B2CYP1A2CHRM2 | |
| SCHEMBL8810482 | 0.89 | HRH3 (0.84) | HRH3KDM4EGUCY1B2CYP1A2CHRM2 | |
| Benzydamine SCHEMBL7135139 | 0.89 | HRH3 (0.83) | HRH3KDM4EGUCY1B2CYP1A2CHRM2 | |
| Benzydamine SCHEMBL28223703 | 0.89 | HRH3 (0.83) | HRH3KDM4EGUCY1B2CYP1A2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220273637-A1 | NOVEL PFAR-INHIBITING COMPOUNDS | Institut National de la Santé et de la Recherche Médicale (FR) | 2022-09-01 | — | — | US | disclosed |
| CN-112514904-B | Application of benzydamine hydrochloride in preparation of bactericide for preventing and treating plant diseases caused by plant pathogenic bacteria | 青岛农业大学 | 2021-10-26 | — | — | CN | disclosed |
| CN-111803495-B | Application of benzydamine hydrochloride in preparation of antitumor drugs | 郑州大学 | 2021-04-23 | — | — | CN | disclosed |
| CN-111803495-B | Application of benzydamine hydrochloride in preparation of antitumor drugs | 郑州大学 | 2021-04-23 | — | — | CN | disclosed |
| CN-112514904-A | Application of benzydamine hydrochloride in preparation of bactericide for preventing and treating plant diseases caused by plant pathogenic bacteria | 青岛农业大学 | 2021-03-19 | — | — | CN | disclosed |
| CN-111803495-A | Application of benzydamine hydrochloride in preparation of antitumor drugs | 郑州大学 | 2020-10-23 | — | — | CN | disclosed |
| CN-111803495-A | Application of benzydamine hydrochloride in preparation of antitumor drugs | 郑州大学 | 2020-10-23 | — | — | CN | disclosed |
| EP-2576778-B1 | TRANSGENIC REPORTER SYSTEM THAT REVEALS EXPRESSION PROFILES AND REGULATION MECHANISMS OF ALTERNATIVE SPLICING IN RODENTS | UNIV KYOTO (JP) | 2017-08-09 | — | — | EP | disclosed |
| US-9273364-B2 | Transgenic reporter system that reveals expression profiles and regulation mechanisms of alternative splicing in mammalian organisms | KYOTO UNIVERSITY (JP) | 2016-03-01 | — | — | US | disclosed |
| US-20130137099-A1 | TRANSGENIC REPORTER SYSTEM THAT REVEALS EXPRESSION PROFILES AND REGULATION MECHANISMS OF ALTERNATIVE SPLICING IN MAMMALIAN ORGANISMS | KYOTO UNIVERSITY (JP) | 2013-05-30 | — | — | US | disclosed |
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |