Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK5 | P34947 | 3/20 | 0.77 |
| ▸ | KDR | P35968 | 14/20 | 0.67 |
| ▸ | PRKAA1 | Q13131 | 11/20 | 0.67 |
| ▸ | PRKAA2 | P54646 | 10/20 | 0.67 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.67 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.67 |
| ▸ | EGFR | P00533 | 3/20 | 0.65 |
| ▸ | FLT3 | P36888 | 3/20 | 0.65 |
| ▸ | CSF1R | P07333 | 3/20 | 0.65 |
| ▸ | PLK4 | O00444 | 2/20 | 0.65 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.65 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.65 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.65 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.65 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.65 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.65 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.65 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.65 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.65 |
| ▸ | INSR | P06213 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16488306 | 1.00 | GRK5 (0.77) | GRK5KDRPRKAA1PRKAA2PDGFRB | |
| SCHEMBL16466858 | 0.94 | GRK5 (0.85) | GRK5KDRPRKAA1PRKAA2PDGFRB | |
| SCHEMBL16466853 | 0.94 | GRK5 (0.85) | GRK5KDRPRKAA1PRKAA2PDGFRB | |
| SCHEMBL16466653 | 0.94 | GRK5 (0.85) | GRK5KDRPRKAA1PRKAA2PDGFRB | |
| SCHEMBL16466657 | 0.94 | GRK5 (0.85) | GRK5KDRPRKAA1PRKAA2PDGFRB | |
| SCHEMBL25311031 | 0.87 | GRK5 (1.00) | GRK5KDRPRKAA1PRKAA2PDGFRB | |
| SCHEMBL16466668 | 0.87 | GRK5 (1.00) | GRK5KDRPRKAA1PRKAA2PDGFRB | |
| SCHEMBL16466800 | 0.87 | GRK5 (1.00) | GRK5KDRPRKAA1PRKAA2PDGFRB | |
| SCHEMBL16466664 | 0.87 | GRK5 (1.00) | GRK5KDRPRKAA1PRKAA2PDGFRB | |
| SCHEMBL25311040 | 0.87 | GRK5 (1.00) | GRK5KDRPRKAA1PRKAA2PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015022437-A1 | INDOLINONE DERIVATIVES AS GRK5 MODULATORS | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2015-02-19 | — | — | WO | disclosed |
| EP-2837626-A1 | Indolinone derivatives as GRK5 modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2015-02-18 | — | — | EP | disclosed |