Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | ULK1 | O75385 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 2/20 | 0.33 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 2/20 | 0.32 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16494735 | 0.91 | KDR (0.34) | KDREGFRPDGFRBULK1DHFR | |
| SCHEMBL16494704 | 0.90 | KDR (0.37) | KDREGFRPDGFRBULK1DHFR | |
| SCHEMBL16495033 | 0.88 | SYK (0.39) | ULK1DHFRPLK2 | |
| SCHEMBL2598786 | 0.88 | PLK2 (0.41) | KDRULK1DHFRPLK2CDK1 | |
| SCHEMBL2598707 | 0.86 | EPHB4 (0.42) | — | |
| SCHEMBL16494296 | 0.86 | SYK (0.40) | KDREGFRPDGFRBULK1DHFR | |
| SCHEMBL16495173 | 0.81 | EGFR (0.35) | KDREGFRULK1DHFRFLT1 | |
| SCHEMBL2598631 | 0.80 | PIK3CA (0.42) | DHFRPLK2 | |
| SCHEMBL2598767 | 0.80 | SYK (0.41) | PLK2 | |
| SCHEMBL16494266 | 0.80 | HTR2A (0.37) | KDRULK1DHFRCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2395001-A1 | Novel pyrimidine derivatives | Chemilia AB (SE) | 2011-12-14 | — | — | EP | disclosed |