Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.81 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.56 |
| ▸ | ESR1 | P03372 | 2/20 | 0.56 |
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | ELANE | P08246 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.47 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CETP | P11597 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL204887 | 0.97 | DHODH (0.76) | DHODHESR2ESR1IKBKBELANE | |
| SCHEMBL505539 | 0.90 | DHODH (1.00) | DHODHESR2ESR1ELANEHTR3A | |
| SCHEMBL205922 | 0.89 | DHODH (0.64) | DHODHESR2ESR1IKBKBHTR3A | |
| SCHEMBL16495294 | 0.88 | DHODH (0.64) | DHODHESR2ESR1IKBKBHTR3A | |
| SCHEMBL3703337 | 0.87 | DHODH (0.62) | DHODHESR2ESR1HTR3ANPC1 | |
| SCHEMBL204513 | 0.87 | DHODH (0.62) | DHODHESR2ESR1IKBKBELANE | |
| SCHEMBL121400 | 0.86 | DHODH (0.94) | DHODHESR2ESR1ELANEHTR3A | |
| SCHEMBL205559 | 0.86 | DHODH (0.59) | DHODHESR2ESR1HTR3AMTNR1A | |
| SCHEMBL205794 | 0.84 | DHODH (0.59) | DHODHESR2ESR1HTR3APARP1 | |
| SCHEMBL205308 | 0.83 | DHODH (0.56) | DHODHESR2ESR1IKBKBPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110293744-A1 | BENZOXAZOLE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE | ABBOTT LABORATORIES (US) | 2011-12-01 | — | — | US | claimed |
| US-20110293744-A1 | BENZOXAZOLE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE | ABBOTT LABORATORIES (US) | 2011-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110293744-A1 | BENZOXAZOLE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE | PARP1, PARP2, PARP3 | DHODH 734/4885ESR2 3623/4885ESR1 4695/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.