Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 1.00 |
| ▸ | JAK3 | P52333 | 10/20 | 1.00 |
| ▸ | JAK1 | P23458 | 9/20 | 1.00 |
| ▸ | USP1 | O94782 | 10/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1693475 | 1.00 | JAK2 (1.00) | JAK2JAK3JAK1USP1 | |
| SCHEMBL1693150 | 1.00 | JAK2 (1.00) | JAK2JAK3JAK1USP1 | |
| SCHEMBL1693514 | 0.89 | JAK2 (0.81) | JAK2JAK3JAK1USP1 | |
| SCHEMBL1693517 | 0.89 | JAK2 (0.81) | JAK2JAK3JAK1USP1 | |
| SCHEMBL1693853 | 0.88 | JAK2 (1.00) | JAK2JAK3JAK1USP1 | |
| SCHEMBL1693851 | 0.88 | JAK2 (1.00) | JAK2JAK3JAK1USP1 | |
| SCHEMBL1693266 | 0.88 | JAK2 (1.00) | JAK2JAK3JAK1USP1 | |
| SCHEMBL1693268 | 0.88 | JAK2 (1.00) | JAK2JAK3JAK1USP1 | |
| SCHEMBL1693463 | 0.88 | JAK2 (1.00) | JAK2JAK3JAK1USP1 | |
| SCHEMBL1693489 | 0.86 | JAK2 (0.77) | JAK2JAK3JAK1USP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2397482-A1 | Heteroaryl imidazolone derivatives as jak inhibitors | Almirall, S.A. (ES) | 2011-12-21 | — | — | EP | disclosed |