Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 20/20 | 1.00 |
| ▸ | EPAS1 | Q99814 | 20/20 | 1.00 |
| ▸ | EP300 | Q09472 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14071200 | 0.87 | HIF1A (0.77) | HIF1AEPAS1EP300 | |
| SCHEMBL14916511 | 0.84 | HIF1A (1.00) | HIF1AEPAS1EP300 | |
| SCHEMBL2563997 | 0.83 | HIF1A (1.00) | HIF1AEPAS1EP300 | |
| SCHEMBL14071509 | 0.80 | HIF1A (0.67) | HIF1AEPAS1EP300 | |
| SCHEMBL14916669 | 0.80 | HIF1A (1.00) | HIF1AEPAS1EP300 | |
| SCHEMBL14063550 | 0.79 | HIF1A (0.65) | HIF1AEPAS1EP300 | |
| SCHEMBL15051844 | 0.76 | EP300 (0.67) | HIF1AEPAS1EP300 | |
| SCHEMBL14071516 | 0.75 | HIF1A (0.75) | HIF1AEPAS1EP300 | |
| SCHEMBL15052061 | 0.75 | EP300 (0.68) | HIF1AEPAS1EP300 | |
| SCHEMBL14071199 | 0.75 | HIF1A (0.76) | HIF1AEPAS1EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071795-B2 | Hypoxia inducible factor (Hif); for modulating mRNA translation within cells; prevents excessive vascularization | EMORY UNIVERSITY (US) | 2011-12-06 | — | — | US | claimed |