⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10257125 | 0.81 | CHRM2 (0.59) | — | |
| SCHEMBL966552 | 0.75 | — | — | |
| SCHEMBL7914134 | 0.74 | — | — | |
| SCHEMBL936173 | 0.73 | — | — | |
| SCHEMBL937076 | 0.73 | CHRM2 (0.52) | — | |
| SCHEMBL3989603 | 0.71 | — | — | |
| SCHEMBL30902061 | 0.71 | CHRM2 (0.50) | — | |
| SCHEMBL11061058 | 0.69 | CHRM1 (0.48) | — | |
| SCHEMBL3362784 | 0.69 | CHRM2 (0.48) | — | |
| SCHEMBL135037 | 0.69 | CHRM1 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-B1 | METHODS OF USING MEK INHIBITORS | EXELIXIS INC (US) | 2018-10-10 | — | — | EP | claimed |
| US-20120294938-A1 | PHARMACEUTICAL PREPARATION FOR ORAL ADMINISTRATION WITH CONTROLLED ACTIVE INGREDIENT RELEASE IN THE SMALL INTESTINE AND METHOD FOR ITS PRODUCTION | Dr. R. Pflefger Chemische Fabrik GmbH (DE) | 2012-11-22 | — | — | US | claimed |
| US-7846959-B2 | Raf modulators and methods of use | EXELIXIS, INC. (US) | 2010-12-07 | — | — | US | claimed |
| US-20090285891-A1 | Pharmaceutical preparation for oral administration with controlled active ingredient release in the small intestine and method for its production | DR. R. PFLEGER CHEMISCHE FABRIK GMBH (DE) | 2009-11-19 | — | — | US | claimed |
| EP-2101759-A1 | METHODS OF USING MEK INHIBITORS | Exelixis, Inc. (US) | 2009-09-23 | — | — | EP | claimed |
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |
| WO-2008076415-A1 | METHODS OF USING MEK INHIBITORS | EXELIXIS, INC. (US) | 2008-06-26 | — | — | WO | claimed |
| US-20080009488-A1 | Raf Modulators and Methods of Use | EXELIXIS, INC. (US) | 2008-01-10 | — | — | US | claimed |
| US-20060188554-A1 | Transdermal absorption preparation | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2006-08-24 | — | — | US | claimed |
| EP-2101759-B1 | METHODS OF USING MEK INHIBITORS | EXELIXIS INC (US) | 2018-10-10 | — | — | EP | disclosed |
| US-8697737-B2 | Raf modulators and methods of use | EXELIXIS, INC. (US) | 2014-04-15 | — | — | US | disclosed |
| US-20120294938-A1 | PHARMACEUTICAL PREPARATION FOR ORAL ADMINISTRATION WITH CONTROLLED ACTIVE INGREDIENT RELEASE IN THE SMALL INTESTINE AND METHOD FOR ITS PRODUCTION | Dr. R. Pflefger Chemische Fabrik GmbH (DE) | 2012-11-22 | — | — | US | disclosed |
| US-8221787-B2 | Pharmaceutical preparation for oral administration with controlled active ingredient release in the small intestine and method for its production | Dr. Robert Pfleger Chemische Fabrik GmbH (DE) | 2012-07-17 | — | — | US | disclosed |
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| WO-2004039763-A1 | QUATERNARY AMMONIUM COMPOUNDS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-05-13 | — | — | WO | disclosed |
| JP-2001048783-A | PERCUTANEOUSLY ABSORBABLE TYPE THERAPEUTIC AGENT FOR POLLAKIURIA AND INCONTINENCE OF URINE | LEAD CHEMICAL CO LTD | 2001-02-20 | — | — | JP | disclosed |
| US-5719155-A | CARDIOVASCULAR DISORDERS | JAPAN TOBACCO INC. (JP) | 1998-02-17 | — | — | US | disclosed |
| EP-0677519-A1 | CHROMAN DERIVATIVE AND MEDICINAL USE THEREOF | Japan Tobacco Inc. (JP) | 1995-10-18 | — | — | EP | disclosed |
| EP-0250125-B1 | DRUG DELIVERY DEVICE, ITS PREPARATION AND USE | Smith & Nephew plc (GB) | 1991-09-18 | — | — | EP | disclosed |
| US-4784857-A | Drug delivery device, its preparation and use | SMITH AND NEPHEW ASSOCIATED COMPANIES PLC (GB) | 1988-11-15 | — | — | US | disclosed |