SCHEMBL16498014

SCHEMBL16498014

CC(C)CC(C(=O)N[C@H]1CC[C@@H]2CN(Cc3ccc(C(F)(F)F)cc3)C[C@@H]21)N(C)C(=O)O

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CACNA1B Q00975 19/20 0.59
KCNH2 Q12809 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16497939 1.00 CACNA1B (0.59) CACNA1BKCNH2
SCHEMBL66597 0.91 CACNA1B (0.51) CACNA1BKCNH2
SCHEMBL66596 0.91 CACNA1B (0.51) CACNA1BKCNH2
SCHEMBL2847786 0.90 CACNA1B (0.51) CACNA1BKCNH2
SCHEMBL16497725 0.90 CACNA1B (0.74) CACNA1BKCNH2
SCHEMBL66714 0.89 CACNA1B (0.55) CACNA1BKCNH2
SCHEMBL66595 0.89 CACNA1B (0.55) CACNA1BKCNH2
SCHEMBL66713 0.89 CACNA1B (0.55) CACNA1BKCNH2
SCHEMBL66149 0.89 CACNA1B (0.55) CACNA1BKCNH2
SCHEMBL16497891 0.89 CACNA1B (0.55) CACNA1BKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011149995-A1 NOVEL SUBSTITUTED OCTAHYDROCYCLOPENTA [C]PYRROL-4-AMINES AS CALCIUM CHANNEL BLOCKERS ABBOTT LABORATORIES (US) 2011-12-01 WO disclosed